Drug intelligence / Profile preview

KK2269 + docetaxel

Development stage
Unknown
Lead developer
Kyowa Kirin
Modality
Small Molecules
Administration
Intravenous
01

Overview

KK2269 + docetaxel is an experimental combination therapy under clinical evaluation for advanced or metastatic solid tumors, including gastric adenocarcinoma, gastroesophageal junction adenocarcinoma, esophageal adenocarcinoma, and non-small cell lung cancer (NSCLC), especially after at least one prior systemic therapy.[1][3][5][7] KK2269 is described as an epithelial cell adhesion molecule (EpCAM, also known as TACSTD1) immune modulator that can promote antitumor activity and tumor-specific immune responses when used with docetaxel, a standard chemotherapy agent.[1] Docetaxel is a semi-synthetic taxoid antineoplastic drug that stabilizes microtubules, preventing cell division and inducing apoptosis in cancer cells.[2][4]

Brand names
Beizray
Other names
docetaxel
02

Targets

TUBB1 (β-tubulin 1)CD40 (Cluster of differentiation 40 receptor)EPCAM (Epithelial cell adhesion molecule)

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