KL112-targeting depolymerase

KL112-targeting depolymerase refers to phage-derived recombinant enzymes that specifically target and degrade the KL112 capsular polysaccharide of *Klebsiella pneumoniae*. Developed by researchers at the University of Geneva and Geneva University Hospital, these depolymerases are identified from distinct bacteriophage genera (such as *Webervirus* and *Przondovirus*) and share a conserved catalytic C-terminal domain that dictates their specificity for the KL112 capsule. By enzymatically degrading the protective capsule of multidrug-resistant *K. pneumoniae* (particularly KPC-producing ST15 epidemic lineages), these depolymerases act as anti-virulence agents, reducing bacterial buoyancy and sensitizing the pathogen to host immune clearance or bacteriophage-mediated lysis.

Other names

anti-KL112 depolymeraseanti-KL-112 depolymeraseanti-KL 112 depolymeraseKL112 depolymeraseKL-112 depolymeraseKL 112 depolymeraseKL112-specific depolymeraseKL-112-specific depolymeraseKL 112-specific depolymerase