Drug intelligence / Profile preview

KL251

Development stage: Preclinical
Lead developer: Kolab
Modality: Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
Administration: Oral

Overview

KL251 is a **probiotic candidate** being developed by **Kolab** for **colitis and inflammatory bowel disease**. Based on the provided company pipeline information, it is a preclinical, orally administered live microbial product intended as an anti-inflammatory microbiome therapy rather than a conventional small-molecule drug. In a DSS-induced colitis mouse model, KL251 was reported to suppress pro-inflammatory cytokines including **interferon gamma**, **tumor necrosis factor alpha**, and **interleukin 1 beta**, supporting its proposed mechanism as a microbiome-based modulator of intestinal inflammation.

Targets

IFNG (Interferon gamma)IL1B (Interleukin-1 beta)TNFA (Tumor necrosis factor alpha (soluble))

Beyond the preview

Go deeper on KL251.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on KL251.

Explore the full profile