KL280006

KL280006 is a novel small molecule drug developed as a selective peripheral κ opioid receptor (KOR) agonist. It is designed primarily for the treatment of uremic pruritus and acute pain conditions. The drug acts by targeting the κ opioid receptor to modulate pain and itch signaling pathways in the periphery, thereby reducing central nervous system side effects commonly associated with centrally acting opioids. There are also indications that it may have antagonistic activity at TRPV1 channels, suggesting a potential dual mechanism for managing pruritus and pain. The developer and manufacturer is Sichuan Kelun Botai Biomedicine Co., Ltd., also referred to as Sichuan Kelunbotai Biopharmaceutical Co., Ltd.[1][2][3][10]

Brand names

KL280006KL-280006KL 280006

Other names

KL-280006KL280006KL 280006A277A-277A 277