Drug intelligence / Profile preview

Klein Laxative Tea

Development stage
Unknown
Lead developer
Laboratório Klein
Modality
Small Molecules
Administration
Oral
01

Overview

Klein Laxative Tea is a Brazilian phytotherapeutic formulation traditionally used for the management of chronic constipation. The product is a complex mixture of four botanical ingredients: *Pimpinella anisum* (green anise) fruits, *Foeniculum vulgare* (fennel) fruits, *Sambucus nigra* (elder tree) flowers, and *Cassia angustifolia* (senna) flowers. Its primary laxative action is attributed to the sennosides found in senna, which act as stimulant laxatives. These compounds are metabolized by gut microbiota into active rheinanthrones that irritate the colonic mucosa, thereby inducing peristalsis and inhibiting water reabsorption by targeting electrolyte transporters. The anise and fennel components contribute carminative and antispasmodic effects, which help to reduce the abdominal discomfort, cramping, and flatulence often associated with stimulant laxative use. The tea has been evaluated in randomized, placebo-controlled clinical trials in Brazil to confirm its efficacy in reducing intestinal transit time and improving evacuation frequency.

Brand names
Klein Laxative TeaChá Klein
Other names
Klein phytotherapeutic teaChá de ervas Klein
02

Targets

ATP1A (Sodium/potassium-transporting ATPase)AQP3 (Aquaporin-3 channel protein)PTGER (Prostaglandin E2 receptor)

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