Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
KLS-2031
- Development stage
- Phase 2
- Lead developer
- Kolon Life Science
- Modality
- Gene Therapies
- Administration
- Epidural
01
Overview
KLS-2031 is an investigational recombinant adeno-associated virus serotype 5 gene therapy developed by Kolon Life Science for neuropathic pain. It is a fixed combination of two AAV5 vectors designed to express glutamate decarboxylase 65, glial cell line-derived neurotrophic factor, and interleukin 10 in dorsal root ganglia following transforaminal epidural administration. The expressed factors are intended to reduce pathologic nociceptive hyperexcitability, support neuronal protection, and suppress neuroinflammation. KLS-2031 completed a Phase 1/2a study in neuropathic pain caused by lumbosacral radiculopathy, with a long-term follow-up study ongoing. ([rcastoragev2.blob.core.windows.net](https://rcastoragev2.blob.core.windows.net/d4798b9bd7c2245a3a1fc3e138c3271a/PMC7378317.pdf))
02
Targets
GFRA1 (Glial cell line-derived neurotrophic factor family receptor alpha 1)IL10RA (Interleukin-10 Receptor)GluR (Glutamate receptors)GDNF (Glial cell line-derived neurotrophic factor)GAD2 (Glutamic Acid Decarboxylase 65)IL10 (Interleukin-10)
Beyond the preview
Go deeper on KLS-2031.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on KLS-2031.