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KM602
- Development stage
- Phase 1
- Lead developer
- Xuanzhu Biopharmaceutical
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Classical Binding Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
KM602 is a recombinant fusion protein composed of the extracellular domain of human CD80 (B7.1) fused to a human immunoglobulin G1 (IgG1) Fc fragment. It is being developed as an antineoplastic agent with potential immunostimulatory and immune checkpoint inhibitory activities. The drug is designed to modulate immune responses against tumors by targeting pathways involved in T cell activation and immune evasion. Its primary indication under investigation is for advanced solid tumors, including inoperable or metastatic disease settings[1][2][3][4][5].
- Other names
- CD80-Fc fusion protein KM602CD-80-Fc fusion protein KM602CD 80-Fc fusion protein KM602recombinant human CD80 mutant-Fc fusion protein
02
Targets
CD28 (Cluster of Differentiation 28)CTLA-4 (Cytotoxic t-lymphocyte–associated protein 4)CD80 (T-lymphocyte activation antigen CD80)
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