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KMCAR T cell
- Development stage
- Unknown
- Lead developer
- HaemaLogiX
- Modality
- CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
KMCAR™ T-cell (KMCAR T cell) is an autologous chimeric antigen receptor (CAR) T-cell therapy developed by HaemaLogiX for the treatment of relapsed or refractory kappa-restricted multiple myeloma. The therapy targets the Kappa Myeloma Antigen (KMA), a tumor-specific receptor expressed exclusively on malignant plasma cells and absent from healthy immune cells. KMCAR is derived from the proprietary KappaMab™ antibody platform. The manufacturing process involves harvesting a patient's own T cells, genetically engineering them to express a CAR directed against KMA, and reinfusing the expanded cells as a single-dose 'living drug.' It is currently being evaluated in the first-in-human Phase 1 KOALA trial in Australia.
- Brand names
- KMCAR
- Other names
- KMCAR T-cell
02
Targets
Immunoglobulin light chain
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