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KN5503
- Development stage
- Preclinical
- Lead developer
- Rui Therapeutics
- Modality
- CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
KN5503 is a chimeric antigen receptor (CAR)-engineered natural killer (NK) cell therapy currently in early-stage preclinical development by Rui Therapeutics (Shenzhen Enrui Kainuo Biotechnology Co., Ltd.). As part of the company's CAR-NK technology platform, the therapy is designed to leverage the innate cytotoxic capabilities of NK cells, enhanced with a CAR to specifically recognize and eliminate target-expressing cells. While the specific molecular target and primary disease indication for KN5503 have not yet been publicly disclosed, it is categorized as a "First-in-Class" candidate within the developer's pipeline.
02
Targets
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