Drug intelligence / Profile preview

Koftab

Development stage
Unknown
Lead developer
Omnica Laboratories
Modality
Small Molecules
Administration
Oral
01

Overview

Koftab is a combination oral tablet developed by Omnica Laboratories, primarily indicated for the symptomatic relief of cough, nasal congestion, sneezing, and other symptoms associated with the common cold, allergic rhinitis, and hay fever. It is formulated as a fixed-dose combination containing three active ingredients: bromhexine hydrochloride (a mucolytic agent that reduces mucus viscosity to facilitate clearance), phenylephrine hydrochloride (a selective alpha-1 adrenergic receptor agonist that acts as a nasal decongestant by constricting blood vessels in the nasal mucosa), and chlorpheniramine maleate (a first-generation histamine H1 receptor antagonist that alleviates allergic symptoms such as sneezing and runny nose).

Brand names
Cosome ExpectorantKoftabNepex Expectorant
Other names
Bromhexine + Chlorpheniramine + PhenylephrineBromhexine Hydrochloride + Chlorpheniramine Maleate + Phenylephrine Hydrochloride
02

Targets

ADRA1A (α1A)ADRA1B (α1B)ADRA1D (α1D)HRH1 (Histamine H1 Receptor)

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