kolaviron

Kolaviron is a **biflavonoid complex** isolated from the seeds of *Garcinia kola* (bitter kola), composed primarily of kolaflavanone, Garcinia biflavonoid GB1, and GB2[1][3][5]. It is not a conventional pharmaceutical but a patented natural product mixture used in traditional medicine. **Kolaviron exhibits a wide spectrum of pharmacological activities** including antioxidant, anti-inflammatory, hepatoprotective, antigenotoxic, neuroprotective, antihyperglycemic, antimicrobial, antidiabetic, and potentially anticancer effects[1][3][7][8]. Mechanistically, kolaviron acts mainly by modulating oxidative stress pathways, boosting antioxidant enzyme activity (e.g., glutathione-S-transferase, superoxide dismutase, catalase), suppressing proinflammatory cytokines (e.g., IL-1β, TNF-alpha, IL-6), and regulating lipid and glucose metabolism[1][3][8][12]. Its precise molecular targets are multiple and include both direct antioxidative actions and modulation of inflammatory signaling pathways, such as nuclear factor-kappa B (NF-κB) and Nrf2[3]. Most evidence comes from preclinical animal and cell models, with emerging interest in its use for liver diseases, diabetes, and inflammation-associated conditions[4][7][11]. No regulatory-approved pharmaceutical formulation or large-scale clinical trials are reported as of the current date.

Brand names

kolaviron

Other names

kolaflavanoneGarcinia biflavonoid GB1Garcinia biflavonoid GB2kolaflavanone (for mixture)biflavonoid complex of Garcinia kola