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konjac glucomannan-curcumin complex in porous starch microspheres
- Development stage
- Preclinical
- Lead developer
- Hubei University of Technology
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
KGM-CUR + PSM is a research-stage nutraceutical delivery system consisting of a **konjac glucomannan (KGM)** and **curcumin (CUR)** complex encapsulated within **porous starch microspheres (PSM)**. This formulation is designed to overcome the inherent limitations of curcumin, such as poor aqueous solubility, low chemical stability, and rapid metabolism. In this system, KGM acts as a stabilizer and film-forming agent that complexes with curcumin, while the porous starch microspheres serve as a high-surface-area carrier that protects the complex from degradation in the upper gastrointestinal tract. The combination allows for the sustained and controlled release of curcumin, primarily targeting the lower digestive system. This delivery platform is investigated for its potential in functional foods and therapeutic applications involving curcumin's antioxidant and anti-inflammatory properties.
- Other names
- KGM-CUR + PSMKGM-CUR/PSMkonjac glucomannan-curcumin/porous starch microspheres
02
Targets
NF-κBTNFA (Tumor necrosis factor alpha (soluble))PTGS2 (Prostaglandin-Endoperoxide Synthase 2)
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