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KOR-CRISPR-Cas9
- Development stage
- Preclinical
- Modality
- CRISPR-Cas9 → CRISPR Systems → Programmable Nucleases → Gene Editing → Gene Therapies
- Administration
- Intracerebral
01
Overview
KOR-CRISPR-Cas9 is an experimental gene-editing tool designed to knock out the kappa opioid receptor (KOR) gene using the CRISPR-Cas9 system. In research settings, it has been employed to investigate the role of hypothalamic KOR signaling in migraine pathophysiology. By deleting KOR in the arcuate nucleus, researchers demonstrated a prevention of stress-induced prolactin release and subsequent trigeminal nociceptor sensitization in female mice. This tool is primarily used for functional genomics and target validation in the study of stress-induced pain and neurological disorders. It represents a targeted genetic approach to inhibiting KOR signaling permanently in specific brain regions.
- Other names
- CRISPR-Cas9 targeting KORCRISPR-Cas-9 targeting KORCRISPR-Cas 9 targeting KORKOR gene knockout construct
02
Targets
KOR (Kappa opioid receptor)
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