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KOS-1584
- Development stage
- Phase 2
- Lead developer
- Bristol Myers Squibb
- Modality
- RNA-Targeting Small Molecules → Nucleic Acid-Directed Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
KOS-1584 is a second-generation synthetic epothilone with potential antineoplastic (anticancer) activity. It acts as a microtubule-stabilizing agent by binding to tubulin and inducing microtubule polymerization, which leads to rapid G2/M cell cycle arrest and apoptosis in cancer cells. Compared to earlier epothilones such as Epothilone D, KOS-1584 demonstrates higher potency (3–12 fold), improved pharmacokinetic properties including enhanced tumor tissue penetration and reduced central nervous system exposure, and favorable tolerability. It was developed primarily for the treatment of advanced solid tumors—including non-small cell lung cancer—and has shown activity in various tumor types resistant to taxanes[2][3][4][5][6][7][8].
- Other names
- epothilone KOS-1584
02
Targets
TUBB (Tubulin (alpha and beta subunits))
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