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Drug intelligence / Profile preview
Kostaive Bivalent
- Development stage
- Unknown
- Lead developer
- CSL Seqirus
- Modality
- Vaccines & Immunotherapeutics, mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intramuscular
01
Overview
Kostaive Bivalent (ARCT-2301) is a self-amplifying mRNA (sa-mRNA) vaccine developed by Arcturus Therapeutics in collaboration with CSL for the prevention of COVID-19. It utilizes Arcturus's proprietary LUNAR lipid nanoparticle delivery system and STARR self-amplifying mRNA technology. As a bivalent vaccine, it is designed to encode the spike proteins of two different SARS-CoV-2 variants—typically the ancestral strain and an Omicron variant—to provide broader immune protection against evolving viral strains. Unlike conventional mRNA vaccines, sa-mRNA contains the genetic instructions for its own replication once inside the host cell, which potentially allows for lower dosing levels and a more robust, durable immune response.
- Brand names
- Kostaive
- Other names
- ARCT-2301ARCT2301ARCT 2301LUNAR-COV19 BivalentLUNAR-COV-19 BivalentLUNAR-COV 19 Bivalent
02
Targets
SARS-CoV-2 spike
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