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Koukuiqing is a Traditional Chinese Medicine (TCM) formulation primarily indicated for the treatment of recurrent aphthous ulcers (RAU). It is a proprietary Chinese medicine that typically functions by clearing heat, detoxifying, and promoting the healing of the oral mucosa. The medication is available in various dosage forms, including oral granules and topical sprays. Koukuiqing works through a multi-target anti-inflammatory mechanism, modulating the levels of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and various interleukins (IL-1β, IL-6). By reducing local inflammation and providing a protective effect on the oral mucosa, it effectively shortens the healing time of ulcers and alleviates associated pain.
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