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KpnB1 siRNA
- Development stage
- Preclinical
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intravenous
01
Overview
KpnB1 siRNA is an experimental research reagent consisting of small interfering RNA (siRNA) designed to silence the expression of the *KPNB1* gene (also known as karyopherin beta-1 or importin beta-1). KPNB1 is a nuclear transport receptor that facilitates the translocation of cargo proteins into the cell nucleus. In preclinical oncology research, KpnB1 siRNA is used to knock down KPNB1 expression, which has been shown to inhibit cell proliferation and induce apoptosis in various cancer cell lines, including epithelial ovarian cancer (EOC) and chronic myeloid leukemia (CML). It serves primarily as a tool for validating KPNB1 as a therapeutic target rather than being a clinical-stage drug candidate itself.
- Other names
- KPNB1 siRNAKPNB-1 siRNAKPNB 1 siRNAkaryopherin beta-1 siRNAimportin beta-1 siRNA
02
Targets
KPNB1 (Importin subunit beta-1)
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