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KQ-2002

Development stage: Phase 2
Lead developer: Novatim Immune Therapeutics
Modality: CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Gene Therapies
Administration: Intravenous

Overview

KQ-2002 is an autologous, bispecific Chimeric Antigen Receptor (CAR) T-cell therapy designed to target both CD19 and CD22 antigens on B-cell surfaces. This dual-targeting approach is intended to enhance therapeutic efficacy and prevent disease relapse caused by antigen escape, a common mechanism of resistance in single-antigen targeted CAR-T therapies where cancer cells lose expression of the targeted protein (typically CD19). KQ-2002 is manufactured on-site (point-of-care) at specialized facilities and is currently being investigated for the treatment of adult patients with relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL) and B-cell non-Hodgkin lymphoma (B-NHL).

Other names: anti-CD19/CD22 CAR-T cellsCD19/CD22 dual-targeted CAR-T cells

Targets

CD19 (B lymphocyte antigen CD19)CD22 (Cluster of Differentiation 22)

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