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Krka refers to the generic pharmaceutical products, specifically statins such as rosuvastatin (marketed as Roswera) and atorvastatin (marketed as Atoris), manufactured by the Slovenian pharmaceutical company Krka, d. d., Novo Mesto. In the context of clinical research at Rigshospitalet (Copenhagen University Hospital), these generic medications have been evaluated in Phase 4 clinical trials (such as NCT02425579 and NCT02425566) to assess their efficacy and safety in patients with myocardial infarction and coronary artery disease. These agents function as HMG-CoA reductase inhibitors, which lower plasma cholesterol levels by inhibiting the endogenous synthesis of cholesterol in the liver and increasing the expression of LDL receptors on hepatocytes, thereby reducing the risk of major adverse cardiovascular events.
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