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KRP-A218 + itraconazole
- Development stage
- Unknown
- Lead developer
- Kyorin Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
KRP-A218 + itraconazole is a drug combination used in clinical pharmacology studies to evaluate the impact of CYP3A4 inhibition on the pharmacokinetics of KRP-A218. KRP-A218 (also known as HAR-1234) is a novel, orally active small molecule developed by Kyorin Pharmaceutical that acts as an ATP-competitive and subtype-specific inhibitor of phosphatidylinositol 4-kinase beta (PI4KB). By targeting this host cell factor, KRP-A218 inhibits the replication of RNA viruses such as human rhinovirus (HRV) and enteroviruses (EV). Itraconazole, a potent antifungal agent, is utilized in this combination as a strong CYP3A4 inhibitor to assess potential drug-drug interactions during Phase I clinical development.
- Other names
- HAR-1234 + itraconazole
02
Targets
PI4KB (Phosphatidylinositol 4-kinase beta)VDAC1 (Hexokinase 2–voltage-dependent anion channel 1 complex)CYP3A (CYP3A family)
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