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KS-40070

Development stage: Preclinical
Lead developer: Therasid Bioscience
Modality: Small Molecules

Overview

KS-40070 is a selective small molecule inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B). DYRK1B is a member of the DYRK family of kinases that plays a critical role in the regulation of the cell cycle and adipocyte differentiation. High expression of DYRK1B has been linked to metabolic disorders, including obesity and type 2 diabetes. KS-40070 demonstrates anti-adipogenic effects by inhibiting the differentiation of preadipocytes into mature adipocytes and shows potential anti-diabetic activity, possibly through the modulation of FOXO1A signaling. It is currently in the discovery or preclinical stage of development for the treatment of metabolic diseases.

Other names: N-(4-(3-(4-methoxyphenyl)-1H-pyrazolo [3,4-b]pyridin-5-yl) phenyl)acetamide

Targets

DYRK1B (Dual specificity tyrosine-phosphorylation-regulated kinase 1B)DYRK2 (Dual-specificity tyrosine-phosphorylation-regulated kinase 2)

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