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KS104 is a Klotho-targeted therapeutic candidate being developed by Klotho Sciences Australia, currently in the IND-enabling phase for the treatment of muscular dystrophy (MD). The drug is part of a pipeline focused on leveraging the biological properties of the Klotho protein, a pleiotropic factor known for its anti-aging, anti-fibrotic, and regenerative effects. KS104 is intended to restore or augment Klotho signaling, which typically declines in degenerative muscle conditions, thereby enhancing muscle repair mechanisms and inhibiting the TGF-beta-mediated fibrotic pathways that contribute to disease progression in MD.
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