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Kshar Sutra is an ancient Ayurvedic para-surgical medicated thread used primarily for the treatment of complex anorectal conditions, such as fistula-in-ano, hemorrhoids, and pilonidal sinus. The thread, typically a surgical linen thread (No. 20), is prepared through a multi-stage coating process involving the latex of *Snuhi* (*Euphorbia neriifolia*), the alkaline ash or *Kshar* of *Apamarga* (*Achyranthes aspera*), and the powder of *Haridra* (*Curcuma longa*). The mechanism of action is dual: it provides mechanical cutting of the fistulous track similar to a seton, while the chemical coating facilitates simultaneous debridement, drainage, and antiseptic action. The *Snuhi* latex contains proteolytic enzymes that assist in cutting, the *Apamarga Kshar* provides a caustic alkaline pH (around 9.2) that debrides necrotic tissue, and the *Haridra* acts as an anti-inflammatory and antiseptic agent to promote healing from the base of the wound. This modality is noted for its high success rates and significantly lower recurrence compared to conventional fistulectomy.
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