Drug intelligence / Profile preview

KSHB002

Development stage: Unknown
Lead developer: Kashiv BioSciences
Modality: Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration: Subcutaneous, Intravenous

Overview

KSHB002 is a biosimilar to abatacept, developed by Kashiv BioSciences. It is being evaluated as a costimulation modulator for the treatment of autoimmune diseases, particularly rheumatoid arthritis. Abatacept functions as a T cell activation inhibitor by interfering with the CD80/CD86-CD28 costimulatory signal required for full T-cell activation. KSHB002 has been formulated as a 125 mg/mL pre-filled syringe injection and has demonstrated pharmacokinetic equivalence to the reference product Orencia in Phase I clinical trials, with comparable safety and immunogenicity profiles. Both subcutaneous and intravenous formulations are under development[2][4][6].

Other names: abatacept biosimilar (Kashiv BioSciences)

Targets

CD86 (T-lymphocyte activation antigen CD86)CD80 (T-lymphocyte activation antigen CD80)

Beyond the preview

Go deeper on KSHB002.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on KSHB002.

Explore the full profile