KSL-W

KSL-W is a synthetic antimicrobial decapeptide with the sequence H-Lys-Lys-Val-Val-Phe-Trp-Val-Lys-Phe-Lys-NH2. It has a molecular weight of 1307.67 Da and molecular formula C68H106N16O10. It is a synthesized analogue of KSL (KKVVFKVKFK), designed with an amidated C-terminus (NH2) and improved stability in simulated oral and gastric conditions while maintaining antimicrobial properties. It is typically available in powder form. KSL-W demonstrates broad-spectrum antimicrobial activity against: * Gram-positive bacteria * Gram-negative bacteria * Fungi (e.g., *Candida albicans*) * Viruses It also exhibits immunomodulatory effects, including enhancing neutrophil chemotaxis, increasing F-actin polymerization in neutrophils, and inhibiting oxygen radical production in stimulated neutrophils. It has advanced to human clinical trials for oral health applications, showing safety and proof-of-concept efficacy in reducing plaque and gingival inflammation.