Drug intelligence / Profile preview

Kuan-Sin-Yin

Development stage
Phase 3
Lead developer
Institute of Traditional Medicine
Modality
Small Molecules
Administration
Oral
01

Overview

Kuan-Sin-Yin (KSY) is a traditional Chinese medicinal (TCM) decoction primarily developed and researched in Taiwan for its therapeutic potential in oncology and infectious diseases. The formula consists of a specific combination of botanical extracts, most commonly featuring *Astragalus membranaceus*, *Scutellaria baicalensis*, *Lycium barbarum*, and *Curcuma longa*. In the treatment of hepatocellular carcinoma (HCC), KSY has demonstrated the ability to inhibit tumor growth, migration, and invasion by downregulating key proteins involved in angiogenesis and tissue remodeling, such as vascular endothelial growth factor (VEGF) and matrix metallopeptidase 9 (MMP-9), and by inducing apoptosis through the activation of the caspase cascade. Additionally, KSY has been utilized as a supportive treatment for COVID-19 to modulate the immune system and alleviate respiratory symptoms. As a multi-ingredient herbal product, its efficacy is attributed to the synergistic action of various phytochemicals like baicalin, curcumin, and polysaccharides.

Brand names
Kuan-Sin-Yin
Other names
Kuan-Sin-Yin decoctionKSY decoction寬心飲
02

Targets

MMP9 (Matrix metalloproteinase-9)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)CASP3 (Caspase-3)VEGFA (Vascular endothelial growth factor A)

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