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kudzu root
- Development stage
- Phase 1
- Lead developer
- Natural Pharmacia International
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Kudzu root (Puerariae lobatae Radix) is the tuberous root of Pueraria lobata, a perennial vine in the legume family. It is a traditional Chinese medicine (known as Gegen) with a long history of use for promoting circulation and treating alcohol intoxication. Kudzu root is typically used as a crude root powder or a standardized extract, such as NPI-031 (Alkontrol-Herbal). Its primary active constituents are isoflavones, including puerarin, daidzin, and daidzein. The extract is primarily investigated for reducing alcohol intake in individuals with alcohol use disorder, a mechanism mediated by daidzin's inhibition of mitochondrial aldehyde dehydrogenase (ALDH2). Additionally, due to its phytoestrogenic components, kudzu root has been clinically evaluated for alleviating menopausal symptoms.
- Brand names
- Alkontrol-Herbal
- Other names
- GegenJapanese arrowrootKudzu root extractPueraria lobata rootPueraria lobata root extractPuerariae lobatae Radix
02
Targets
ALDH2 (Mitochondrial Aldehyde Dehydrogenase)ESR1 (ERα)ESR2 (ERβ)
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