Drug intelligence / Profile preview

Kunxian Capsule

Development stage
Phase 4
Lead developer
Guangzhou Chen Li Ji Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

Kunxian Capsule is a **traditional Chinese patent medicine** formulated from four herbal components: Tripterygium hypoglaucum (H.Lév.) Hutch, Epimedium brevicornu Maxim, Cuscuta chinensis Lam, and Lycium barbarum L. Its main indications include **rheumatoid arthritis, nephrotic syndrome, systemic lupus erythematosus, Henoch-Schönlein purpura, IgA nephropathy, ankylosing spondylitis, psoriatic arthritis**, and other autoimmune or inflammatory diseases. Pharmacologically, Kunxian Capsule is recognized for its immunomodulatory and anti-inflammatory actions. Mechanistically, it acts primarily by inhibiting inflammatory networks, modulating PI3K/AKT/mTOR and β-catenin signaling pathways, and suppressing immune cell activation and chemokine production. The key active constituents include terpenoids (e.g., triptolide, celastrol), sesquiterpene pyridines (e.g., wilforgine, wilforine), and flavonoids (e.g., icariin, epimedin A/B/C) derived from its herbal components[1][2][4][5][7].

Brand names
Kunxian CapsuleKunxian Capsules
Other names
KXKXC
02

Targets

PI3K (Phosphoinositide-3-kinase regulatory subunit 6)CTNNB1 (Beta-catenin)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)mTOR (Mammalian target of rapamycin kinase)IL-6 (Interleukin 6)

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