kurarinone

Kurarinone is a naturally occurring prenylated flavanone and a major bioactive component isolated from the roots of Sophora flavescens and other related plants[3][6][7]. It exhibits a broad spectrum of pharmacological activities including antitumor (anticancer), anti-inflammatory, neuroprotective (notably in Parkinson’s disease models), anti-drug resistance, antimicrobial (antifungal and antibacterial), antioxidant, estrogenic effects as well as modulation of metabolic enzymes. Mechanistically, kurarinone acts through multiple pathways such as inhibition of Th1/Th17 cell differentiation via immune modulation[1][9], suppression of STAT3 and Akt signaling pathways[3], selective inhibition of soluble epoxide hydrolase (sEH/Ephx2)[5], and inhibition/modulation of cytochrome P450 enzymes and UDP-glucuronosyltransferases[7]. Kurarinone has shown efficacy in preclinical models for cancer chemoprevention and neurodegenerative diseases like Parkinson’s disease by stabilizing epoxyeicosatrienoic acids through sEH inhibition[5].

Other names

2'-Methoxykurarinone(2S)-2-(2,4-dihydroxyphenyl)-7-hydroxy-5-methoxy-8-(5-methyl-2-prop-1-en-2-ylhex-4-enyl)-2,3-dihydrochromen-4-oneMarini