Drug intelligence / Profile preview

KWZL-7f15

Development stage
Preclinical
Lead developer
China Pharmaceutical University
01

Overview

KWZL-7f15: sourced facts only. name: "Among the newly synthesized compounds, 7f and 7f15 exhibited potent inhibitory activity against both CDK6 and BRD4, along with remarkable antiproliferative activity on TNBC cells." [PMID:41782507]; target: "Among the newly synthesized compounds, 7f and 7f15 exhibited potent inhibitory activity against both CDK6 and BRD4, along with remarkable antiproliferative activity on TNBC cells." [PMID:41782507]; target: "Among the newly synthesized compounds, 7f and 7f15 exhibited potent inhibitory activity against both CDK6 and BRD4, along with remarkable antiproliferative activity on TNBC cells." [PMID:41782507]; developer: "Basic Medical Research Innovation Center for Anti-Cancer Drugs of MOE and Jiangsu Key Laboratory of Bioactive Natural Product Research, China Pharmaceutical University, Nanjing 210009, People's Republic of China." [PMID:41782507]; stage: "In vivo studies using the MDA-MB-231 xenograft mouse model revealed that 7f15 exhibits robust antitumor activity without significant adverse effects." [PMID:41782507]

02

Targets

BRD4 (Bromodomain-containing protein 4)CDK6 (Cyclin-dependent kinase 6)

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