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KY004
- Development stage
- Preclinical
- Lead developer
- KYDES Pharmaceuticals
- Modality
- Inhalation Devices → Device-based Delivery → Drug Delivery Systems, Small Molecules, Implantable Devices → Device-based Delivery → Drug Delivery Systems, Transdermal Patches → Device-based Delivery → Drug Delivery Systems
- Administration
- Vaginal
01
Overview
KY004 (also known as KY1104) is a topical microbicide combination product under development by KYDES Pharmaceuticals for the prevention of HIV infection in high-risk individuals. The product is designed for vaginal administration and is being explored in multiple delivery formats, including gels, tablets, films, and rings. Its mechanism of action utilizes a dual-agent approach: one component is designed to reduce viral integration into the host genome, while the other inhibits viral replication. This combination strategy aims to provide a robust barrier against HIV transmission at the site of entry by targeting two distinct stages of the viral life cycle.
02
Targets
Integrase allosteric pocket (HIV)Human immunodeficiency virus type 1 reverse transcriptase
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