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KYN-5356
- Development stage
- Phase 2
- Lead developer
- Kynexis
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
KYN-5356 is a first-in-class, potent, and highly selective small molecule inhibitor of kynurenine aminotransferase II (KAT-II), a key enzyme in the kynurenine pathway. It is being developed for the treatment of cognitive impairment associated with schizophrenia (CIAS). By inhibiting KAT-II, KYN-5356 reduces levels of kynurenic acid in the brain; elevated kynurenic acid has been implicated as a driver of cognitive dysfunction in schizophrenia. The drug is administered orally and has demonstrated good safety and pharmacokinetic properties in phase 1 studies. Originally discovered by Mitsubishi Tanabe Pharma Corporation (MTPC), it is now being developed by Kynexis Therapeutics under an exclusive worldwide license from MTPC[1][2][3][4][5][7].
- Other names
- KYN 5356KYN5356KYN-5356MT 5356MT5356MT-5356
02
Targets
AADAT (Kynurenine aminotransferase II)
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