L-1-naphthyl-2-acetamido-ethane boronic acid

L-1-naphthyl-2-acetamido-ethane boronic acid is an experimental small molecule compound containing a naphthalene moiety and a boronic acid functional group. It has been studied primarily as a transition-state analog inhibitor of serine proteases, such as chymotrypsin and subtilisin, by forming covalent tetrahedral adducts with the catalytic serine residue in the enzyme active site. This mechanism mimics the transition state of peptide bond hydrolysis, making it useful for probing enzyme stereoselectivity and inhibition mechanisms in biochemical research[8]. The compound is not approved for clinical use or marketed under any brand name[1][2].

Other names

(1R)-1-Acetamido-2-(1-naphthyl)ethyl](trihydroxy)borate(1-)[(1R)-1-acetamido-2-(naphthalen-1-yl)ethyl]trihydroxyboranuide