L-2-18F-FAMP

L-2-18F-FAMP is an L-enantiomeric, 2-position, 18F-fluoro-α-methyl-phenylalanine derivative developed as a tumor imaging agent for positron emission tomography (PET). It is a radiolabeled synthetic amino acid specifically taken up by the L-type amino acid transporter 1 (LAT1), which is highly expressed in many types of tumors. Preclinical PET imaging with L-2-18F-FAMP in tumor xenograft models demonstrates high and selective tumor uptake, rapid blood clearance, and lower renal background signal than older tracers. These properties suggest L-2-18F-FAMP offers improved tumor visualization and pharmacokinetics compared to existing radiolabeled amino acid tracers[4]. The agent functions as a radiopharmaceutical PET tracer for oncology imaging.