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l-2-amino-6-methylene-pimelic acid
- Development stage
- Unknown
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
01
Overview
L‑2‑Amino‑6‑methylene‑pimelic acid is a synthetic, non-proteinogenic amino acid and structural analog of meso-diaminopimelate. It acts as a potent competitive inhibitor of diaminopimelate dehydrogenase, an enzyme involved in the bacterial biosynthesis pathway for meso-diaminopimelate and L‑lysine. This pathway is essential for the growth of certain bacteria but absent in humans, making the enzyme—and its inhibitors—of interest for antibacterial drug development. The compound has been studied primarily as a biochemical probe and experimental tool rather than as a therapeutic agent[1][3][8].
- Other names
- (2S)-2-amino-6-methylideneheptanedioic acidl-2-amino-6-methylene-pimelic acidl2-amino-6-methylene-pimelic acidl 2-amino-6-methylene-pimelic acid(2S)-2-amino-6-methylenheptandisäureAcide (2S)-2-amino-6-méthylèneheptanedioïqueHeptanedioic acid, 2-amino-6-methylene-, (2S)-
02
Targets
DAPDH (Diaminopimelate dehydrogenase)
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