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L-741626 is a potent and selective antagonist for the dopamine receptor D₂. It has good selectivity over the related D₃ and D₄ subtypes. It is used primarily in laboratory research to study the roles of D₂ receptors in the brain and has been explored for its effects on various diseases, including cancer (hepatocellular carcinoma) by acting on pathways like the MAPK/ERK signaling pathway via non-dopamine receptor targets.
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