l-hydroxyproline

L-hydroxyproline (trans-4-hydroxy-L-proline) is a non-essential amino acid and a primary constituent of collagen, where it plays a vital role in stabilizing the collagen triple helix through hydrogen bonding. It is produced biologically via the post-translational hydroxylation of proline residues by the enzyme prolyl hydroxylase. While it is extensively used as a pharmaceutical intermediate in the synthesis of various drugs, most notably the HIV protease inhibitor atazanavir, it also has direct clinical applications. It is utilized as a diagnostic biomarker for conditions involving high collagen turnover, such as bone resorption and liver fibrosis. Therapeutically, l-hydroxyproline is incorporated into topical formulations to promote the repair of superficial wounds by supporting extracellular matrix synthesis. It is commercially produced through fermentation processes, with major suppliers including Evonik.

Brand names

Cicactive

Other names

trans-4-hydroxy-L-prolinetrans4-hydroxy-L-prolinetrans 4-hydroxy-L-proline4-hydroxy-L-proline(4R)-4-hydroxy-L-prolineL-4-hydroxyprolineL4-hydroxyprolineL 4-hydroxyproline