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l-Institut de Recherche pour le Developpement-malaria
- Development stage
- Unknown
- Lead developer
- Institut de Recherche pour le Développement
- Modality
- Recombinant Proteins and Enzymes, Small Molecules, Vaccines & Immunotherapeutics
01
Overview
The designation "l-Institut de Recherche pour le Developpement-malaria" refers to the malaria research and clinical development program led by the Institut de Recherche pour le Développement (IRD), a French public research institution. The program focuses on evaluating and developing interventions for malaria prevention and treatment, particularly in vulnerable populations such as pregnant women and individuals living with HIV in sub-Saharan Africa. A cornerstone of this program is the **PACOME** trial (Phase 3), which evaluated the efficacy of daily **cotrimoxazole** (sulfamethoxazole/trimethoprim) prophylaxis compared to intermittent preventive treatment with **mefloquine** (IPTp-MQ) for the prevention of placental malaria in HIV-infected pregnant women. Additionally, IRD is a lead developer of **PRIMALVAC**, a recombinant protein vaccine candidate targeting the **VAR2CSA** antigen of *Plasmodium falciparum*, which is designed to prevent pregnancy-associated malaria (PAM) by blocking the adhesion of infected erythrocytes to the placenta.
- Other names
- Institut de Recherche pour le Développement malaria programPACOME interventionIRD malaria research
02
Targets
VAR2CSAβ-HematinDHPS (Dihydropteroate synthase)Nucleotide synth (Nucleotide synthesis enzymes)
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