L-isoDMDP

L-isoDMDP is a synthetic carbon-branched iminosugar and a potent, specific competitive inhibitor of gut disaccharidases, particularly rat intestinal maltase (Ki = 0.081 μM). Chemically identified as (2S,3S,4R)-2,4-bis(hydroxymethyl)pyrrolidine-3,4-diol, it is an enantiomer of isoDMDP. In preclinical studies, it has demonstrated superior efficacy in suppressing hyperglycemia during maltose loading tests compared to miglitol, suggesting potential utility in treating late-onset diabetes. Additionally, L-isoDMDP has been investigated for its ability to partially rescue the defective F508del-CFTR protein function in cystic fibrosis cell models, positioning it as a potential pharmacological chaperone similar to miglustat.

Other names

(2S,3S,4R)-2,4-bis(hydroxymethyl)pyrrolidine-3,4-diol