L-K6

L-K6 is a synthetic lysine/leucine-rich cationic antimicrobial peptide (CAP) that is an analog of temporin-1CEb, originally isolated from the skin secretion of the Chinese brown frog, Rana chensinensis. It exhibits broad-spectrum antimicrobial activity against Gram-negative and Gram-positive bacteria, anticancer activity against breast cancer and glioblastoma cells, and anti-inflammatory properties. Its mechanism of action involves permeabilizing bacterial cell membranes, disrupting cancer cell membranes, promoting internalization into cancer cells via endocytosis (caveolae-mediated endocytosis and macropinocytosis), and inducing nuclear damage. For its anti-inflammatory effects, L-K6 neutralizes lipopolysaccharide (LPS) and inhibits inflammatory signaling pathways, specifically the MyD88-dependent pathway, including mitogen-activated protein kinases (MAPKs) and the NF-κB signaling pathway.

Other names

lysine/leucine-rich CAPlysine-/leucine-rich antimicrobial peptidetemporin-1CEb analogtemporin1CEb analogtemporin 1CEb analog