L-N(omega)-nitroarginine-(4R)-amino-L-proline amide

L-N(omega)-nitroarginine-(4R)-amino-L-proline amide is a synthetic small molecule belonging to the class of proline derivatives. It is an experimental compound primarily used as a research tool. The drug acts as an inhibitor of nitric oxide synthase (NOS), thereby reducing the production of nitric oxide, a key signaling molecule involved in vasodilation and neurotransmission. By inhibiting NOS isoforms—including neuronal (NOS1), inducible (NOS2), and endothelial (NOS3)—this compound serves as a valuable probe for studying the physiological and pathophysiological roles of nitric oxide in cardiovascular, neurological, and inflammatory processes[6][10]. There are no approved clinical indications or marketed formulations for this agent.

Other names

L-N(OMEGA)-NITROARGININE-(4R)-AMINO-L-PROLINE AMIDE(2S,4R)-4-[(2S)-2-amino-5-(1-nitrocarbamimidamido)pentanamido]pyrrolidine-2-carboxamidePD008574PD-008574PD 008574N omega-Nitro-L-Arginine-containing dipeptide, 2(4R)-4-{[N~5~-(N-nitrocarbamimidoyl)-L-ornithyl]amino}-L-prolinamide