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L-Panto
- Development stage
- Unknown
- Lead developer
- Lloyd Healthcare
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
L-Panto is a generic fixed-dose combination medication developed and marketed by Lloyd Healthcare, primarily indicated for the management of pain and inflammation associated with orthopedic and musculoskeletal disorders. It contains two active pharmaceutical ingredients: lornoxicam and pantoprazole. Lornoxicam is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class that provides analgesic and anti-inflammatory effects by inhibiting the cyclooxygenase enzymes COX-1 and COX-2, thereby reducing the synthesis of pro-inflammatory prostaglandins. Pantoprazole is a proton pump inhibitor (PPI) that irreversibly inhibits the H+/K+-ATPase pump in gastric parietal cells, reducing gastric acid secretion. The inclusion of pantoprazole in this formulation is intended to mitigate the risk of NSAID-induced gastric mucosal injury and gastrointestinal irritation, making it suitable for patients requiring long-term pain management for conditions such as osteoarthritis and rheumatoid arthritis.
- Brand names
- L-Panto
- Other names
- lornoxicam + pantoprazolelornoxicam/pantoprazole
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)ATP4A (Potassium–transporting ATPase alpha chain 1)PGHS-1 (Prostaglandin G/H Synthase 1)
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