Drug intelligence / Profile preview

l-serine

Development stage
Phase 3
Modality
Small Molecules
Administration
Oral, Intravenous, Dietary Intake (as Supplement)
01

Overview

L-serine is a naturally occurring, non-essential α-amino acid used in the biosynthesis of proteins. It contains an α-amino group, a carboxyl group, and a side chain consisting of a hydroxymethyl group, classifying it as a polar amino acid. L-serine is synthesized in the human body and plays critical roles in cellular metabolism, including serving as a precursor for glycine, cysteine, sphingolipids, purines, pyrimidines, and folate derivatives. It is essential for nucleotide synthesis and central nervous system function. Industrially produced from glycine and methanol via hydroxymethyltransferase catalysis[1][7][9].

Other names
L-丝氨酸serine(S)-2-Amino-3-hydroxypropanoic acid(S)-Serine2-amino-3-hydroxypropanoic acid56-45-1L-(−)-serine(S)-(−)-serineb-Hydroxy-L-alanine
02

Targets

PHGDH (3-Phosphoglycerate dehydrogenase)PSAT1 (Phosphoserine aminotransferase 1)PSPH (Phosphoserine phosphatase)PKM2 (Pyruvate kinase M2 isoform)SHMT2 (Serine hydroxymethyltransferase 2)

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