L-t-C6-Pyr-Cer

L-t-C6-Pyr-Cer is a **synthetic, water-soluble ceramide analog featuring a pyridinium group** attached to a six-carbon (C6) acyl chain, in the L-threo stereochemistry. It is structurally related to ceramides, a family of sphingolipid metabolites involved in cell signaling. This compound is primarily used as a research tool to investigate ceramide signaling and its interaction with protein targets, specifically the inhibition of the SET protein and activation of the tumor suppressor phosphatase PP2A. Mechanistically, certain ceramide species, including pyridinium D-e-C6-ceramide, act as direct SET binders and **PP2A activators**, while their isomers—including "L" stereoisomers—do not activate PP2A, indicating a strong stereoselectivity in biological activity[2]. No approved clinical or therapeutic use is reported for L-t-C6-Pyr-Cer.

Other names

L-t-C6-pyridinium-ceramideL-t-C-6-pyridinium-ceramideL-t-C 6-pyridinium-ceramide