Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
l-tetrahydrofuroic acid
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Intraperitoneal
01
Overview
l-tetrahydrofuroic acid (L-THFA) is a competitive inhibitor of proline dehydrogenase (PRODH, also known as proline oxidase), a mitochondrial inner membrane flavoprotein that catalyzes the first step of proline catabolism. By mimicking the structure of L-proline, l-tetrahydrofuroic acid reversibly binds to the active site of PRODH, blocking the FAD-dependent oxidation of proline to pyrroline-5-carboxylate (P5C). This inhibition disrupts proline-derived mitochondrial ATP production and reactive oxygen species (ROS) generation. Preclinical studies have investigated l-tetrahydrofuroic acid as a chemical probe to evaluate the role of proline catabolism in cancer cell survival, metastasis, and fungal morphogenesis, demonstrating its ability to reduce breast cancer metastasis in mouse models.
- Other names
- L-THFAL-tetrahydro-2-furoic acidL-tetrahydro2-furoic acidL-tetrahydro 2-furoic acidL-tetrahydrofuroic acidtetrahydro-2-furoic acidtetrahydro2-furoic acidtetrahydro 2-furoic acid
02
Targets
PRODH (Proline dehydrogenase 1, mitochondrial)PYCR1/PYCR2 (Pyrroline-5-carboxylate reductases 1/2)
Beyond the preview
Go deeper on l-tetrahydrofuroic acid.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on l-tetrahydrofuroic acid.