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L2-01 adipose-derived mesenchymal stem cells
- Development stage
- Phase 2
- Lead developer
- L2 Bio
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intravenous
01
Overview
L2-01 adipose-derived mesenchymal stem cells are autologous or first-degree blood relative sourced adipose-derived mesenchymal stem cells (AD-MSCs) developed by L2 Bio. The product consists of stem cells harvested from a patient’s own adipose tissue or a close relative, processed and expanded ex vivo, and delivered intravenously. These cells are used for their immunomodulatory and anti-inflammatory properties, particularly for the treatment of Crohn’s Disease. The therapy is notable for its potentially high safety profile, very low risk of rejection, and personalized HLA/DNA matching when using autologous or relative donor tissue. L2 Bio has received FDA approval to conduct a Phase 2B clinical trial in Crohn’s Disease. The cells function by reducing inflammatory responses and inducing regulatory T cells, likely through the secretion of soluble factors such as IL-10, TGF-β, PGE2, and others. L2 Bio is leading the clinical development and banking of these ADSCs for therapeutic use[1][2][4].
- Other names
- L2-01 adipose-derived mesenchymal stem cellsL-2-01 adipose-derived mesenchymal stem cellsL 2-01 adipose-derived mesenchymal stem cellsL2-01 AD-MSCsL-2-01 AD-MSCsL 2-01 AD-MSCsL2 Bio adipose-derived mesenchymal stem cellsL-2 Bio adipose-derived mesenchymal stem cellsL 2 Bio adipose-derived mesenchymal stem cells
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