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L6-F4-2
- Development stage
- Discontinued
- Lead developer
- Stanford University
- Modality
- Vaccines & Immunotherapeutics, Peptides
- Administration
- Injection
01
Overview
L6-F4-2 is an experimental peptide mimotope designed to mimic the L6 tumor-associated antigen (also known as Transmembrane 4 L6 family member 1 or TM4SF1), a protein highly expressed on the surface of various human carcinomas, including lung, breast, colon, and ovarian cancers. Identified through phage display technology, this 12-mer peptide was developed as a cancer vaccine candidate to elicit a humoral immune response. By mimicking the conformational epitope recognized by the L6 monoclonal antibody, L6-F4-2 aims to stimulate the production of endogenous antibodies that cross-react with the L6 antigen on malignant cells, potentially mediating tumor clearance through antibody-dependent cellular cytotoxicity (ADCC). Research on this compound was primarily conducted in the late 1990s by scientists at Bristol Myers Squibb and the Pacific Northwest Research Institute.
- Other names
- L6 mimotope peptideL-6 mimotope peptideL 6 mimotope peptide
02
Targets
FZD4 (Frizzled class receptor 4)TM4SF1 (Transmembrane 4 L6 family member 1)
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