Drug intelligence / Profile preview

labisia pumila extract

Development stage
Preclinical
Lead developer
Medika Natura
Administration
Oral
01

Overview

**Labisia pumila extract** is a botanical extract derived from the Labisia pumila plant, traditionally used in Southeast Asia, particularly Malaysia, for women's reproductive health issues such as facilitating childbirth, treating post-childbirth and menstrual irregularities, and as a health tonic for pre- and postmenopausal women. The extract contains bioactive compounds including flavonoids, phenolic acids, saponins, and phytoestrogens, which contribute antioxidant, anti-inflammatory, antimicrobial, and mild estrogenic activities. Experimental studies suggest mechanisms including modulation of estrogen receptors (acting as a phytoestrogen and partial selective estrogen receptor modulator), effects on lipid metabolism, antioxidant status improvement, and potential modulation of cytochrome P450 enzymes, P-glycoprotein, and pregnane X receptor that may affect drug metabolism. Clinical evidence remains limited, but animal studies indicate potential benefits for postmenopausal symptoms, lipid profiles, bone health, and metabolic processes. The extract is commercially available as capsules, tea, coffee, and other formulations marketed as dietary supplements for women’s health and general wellbeing[1][2][3][4].

Brand names
Labeesity
Other names
kacip fatimah extractselusuh fatimah extractmarantodes pumilum extractlabisia pumila var. alata extractlabisia pothoina extract
02

Targets

CYP2C19 (Cytochrome P450 2C19)CYP1A2 (Cytochrome P450 1A2)ABCB1 (P-glycoprotein)CYP3A4 (Cytochrome P450 3A4)ESR1 (ERα)CYP2C9 (Cytochrome P450 family 2 subfamily C member 9)PXR (Pregnane X receptor)

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