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Labisia pumila var alata extract
- Development stage
- Unknown
- Lead developer
- Medika Natura
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Labisia pumila var alata extract (commonly known as Kacip Fatimah) is a standardized botanical extract derived from the Southeast Asian herb *Labisia pumila* var. *alata*. Developed primarily by Medika Natura (formerly Orchid Life) in collaboration with Universiti Sains Malaysia, the extract is being investigated as a therapeutic agent for obesity, metabolic syndrome, and postmenopausal symptoms. It contains bioactive compounds such as gallic acid and other polyphenols. Mechanistically, the extract acts as a phytoestrogen, binding to estrogen receptors (ERα and ERβ), and has been shown to downregulate 11-beta hydroxysteroid dehydrogenase type 1 (HSD11B1) expression and reduce corticosterone levels in metabolic tissues. In clinical trials, a standardized formulation of the extract (SKF7) demonstrated efficacy in reducing body weight, body mass index, and waist circumference in individuals with obesity.
- Brand names
- Labeesity
- Other names
- Kacip FatimahLabisia pumila var. alata extractLPva
02
Targets
ESR1 (ERα)ESR2 (ERβ)
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