lacidipine

Lacidipine is a lipophilic dihydropyridine calcium channel blocker used primarily for the treatment of hypertension. It acts by selectively inhibiting voltage-dependent L-type calcium channels in vascular smooth muscle, leading to reduced transmembrane calcium influx. This results in relaxation and dilation of peripheral arterioles, lowering blood pressure. Lacidipine has a slow onset and long duration of action due to its high membrane partition coefficient and lipophilicity, which allows it to accumulate within cell membranes and exert sustained effects. Unlike some other dihydropyridine calcium antagonists, lacidipine does not typically cause reflex tachycardia and may possess antioxidant properties that could confer antiatherosclerotic benefits[1][3][7].

Brand names

LacipilMotens

Other names

diethyl 2,6-dimethyl-4-[2-[(E)-3-[(2-methylpropan-2-yl)oxy]-3-oxoprop-1-enyl]phenyl]-1,4-dihydropyridine-3,5-dicarboxylateLacidipinLacidipinaLacidipinoLacidipinum